Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population

Table 3

Association between the genotype distribution of rs237028 and characteristics of the EOC patients.

Clinical features	Genotype			Genetic model								Allele
				Codominant		Dominant		Recessive		Overdominant
				(A/A vs. A/G vs G/G)		(A/A vs. A/G-G/G)		(A/A-A/G vs. G/G)		(A/A-G/G vs. A/G)
	A/A	A/G	G/G	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value	OR (95% CI)	value	A	G	OR (95% CI)	value
Age
<50	41	20	6	A/G: 0.658 (0.306-1.412)	0.281	0.565 (0.276-1.160)	0.118	0.290 (0.057-1.493)	0.115	0.726 (0.341-1.545)	O.406	102	32	0.544 (0.296-1.001)	0.049
≥50	53	17	2	G/G: 0.258 (0.049-1.345)	0.090							123	21
FIGO stage
I-II	31	8	2	A/G: 1.784 (0.730-4.357)	0.201	1.722 (0.756-3.926)	0.193	1.272 (0.246-6.579)	0.564	1.734 (0.715-4.204)	0.220	70	12	1.543 (0.764-3.115)	0.224
III-IV	63	29	6	G/G: 1.476 (0.282-7.741)	0.489							155	41
Grade
G1	6	5	1	A/G: 2.194 (0.623-7.729)	0.182	2.194 (0.662-7.273)	0.161	1.652 (0.182-14.994)	0.510	2.024 (0.597-6.860)	0.205	18	10	2.664 (1.143-6.211)	0.020
G2-G3	79	30	6	G/G: 2.194 (0.226-21.324)	0.437							187	39
Histology
Serous	49	20	5	A/G: 1.056 (0.492-2.286)	0.888	1.122 (0.549-2.295)	0.752	1.473 (0.338-6.423)	0.443	1.024 (0.481-2.180)	0.951	118	30	1.183 (0.647-2.161)	0.585
Others	44	17	3	G/G: 1.497 (0.338-6.628)	0.438							107	23
Tumor position
Unilateral	27	7	3	A/G: 1.815 (0.693-4.753)	0.221	1.429 (0.603-3.387)	0.276	0.453 (0.087-2.362)	0.293	1.905 (0.735-4.939)	0.181	61	13	1.117 (0.544-2.293)	0.762
Bilateral	51	24	3	G/G: 0.529 (0.100-2.804)	0.365							126	30
Lymph node status
Negative	36	16	5	A/G: 0.622 (0.228-1.696)	0.352	0.681 (0.266-1.743)	0.421	1.154 (0.209-6.377)	0.619	0.624 (0.235-1.662)	0.344	88	26	0.802 (0.378-1.703)	0.565
Positive	14	10	2	G/G: 0.972 (0.169-5.607)	0.643							38	14
Peritoneum invasion
Negative	32	13	3	A/G: 0.905 (0.399-2.050)	0.811	0.907 (0.423-1.944)	0.803	0.947 (0.216-4.156)	0.627	0.912 (0.407-2.043)	0.495	77	19	0.925 (0.490-1.747)	0.811
Positive	49	22	5	G/G: 0.919 (0.205-4.114)	0.613							120	32
Vascular invasion
Negative	72	28	8	A/G: 0.500 (0.170-1.472)	0.153	0.643 (0.221-1.866)	0.441	1.080 (1.024-1.139)	0.320	0.450 (0.153-1.322)	0.121	172	44	0.914 (0.371-2.250)	0.844
Positive	9	7	0	G/G: 1.111 (1.033-1.195)	0.410							25	7

CI = confidence interval, FIGO = International Federation of Gynecology and Obstetrics, OR = odds ratio. .