CACNA1C Polymorphism (rs2283291) Is Associated with Schizophrenia in Chinese Males: A Case-Control Study

Table 4

Association analysis of SNP genotype distributions in SCZ patients and the healthy control group as stratified by the gender.

SNP	Model	Genotype	SCZ vs. HC (male)			SCZ vs. HC (female)
			OR (95% CI)		AIC	OR (95% CI)		AIC
rs2283291	Codominant	GG	1.00 (ref)	0.017	670.4	1.00 (ref)	0.74	617.3
		GA	1.52 (1.04-2.22)			0.93 (0.63-1.39)
		AA	0.70 (0.37-1.31)			0.76 (0.38-1.55)
	Dominant	GG	1.00 (ref)	0.13	674.3	1.00 (ref)	0.59	615.6
		GA+AA	1.32 (0.92-1.89)			0.90 (0.62-1.32)
	Recessive	GG+GA	1.00 (ref)	0.064	673.1	1.00 (ref)	0.49	615.4
		AA	0.57 (0.31-1.04)			0.79 (0.40-1.56)
	Overdominant	GG+AA	1.00 (ref)	0.0086	669.7	1.00 (ref)	0.89	615.9
		GA	1.62 (1.13-2.33)			0.97 (0.66-1.42)
rs4648635	Codominant	CC	1.00 (ref)	0.07	673.2	1.00 (ref)	0.57	616.8
		CT	0.82 (0.52-1.29)			1.05 (0.64-1.73)
		TT	—			0.36 (0.04-3.09)
	Dominant	CC	1.00 (ref)	0.6	676.3	1.00 (ref)	0.97	615.9
		CT+TT	0.89 (0.57-1.39)			0.99 (0.61-1.61)
	Recessive	CC+CT	1.00 (ref)	—	—	1.00 (ref)	0.30	614.8
		TT	—			0.35 (0.04-3.06)
	Overdominant	CC+TT	1.00 (ref)	0.35	675.7	1.00 (ref)	0.80	615.9
		CT	0.81 (0.51-1.27)			1.07 (0.65-1.75)

SCZ: schizophrenic; HC: healthy control.