AK4 Promotes the Progression of HER2-Positive Breast Cancer by Facilitating Cell Proliferation and Invasion

Figure 4

AK4 induces tumor growth and metastasis of HER2-positive breast cancer in mice. (a) MCF7 cells infected with control or AK4 shRNA lentivirus were subcutaneously implanted into nude mice. After 2 weeks, tumors were isolated, and the volume of tumor was measured every 7 days ( in each group). Tumor growth curves were calculated and evaluated based on the average volume of 5 tumors in AK4 knockdown and control groups. (b) MCF7 cells infected with control or AK4 shRNA lentivirus were implanted into the caudal vein of nude mice. After 8 weeks, tumors were isolated from mice in each group and weighted ( for each group). (c) IHC assays showed the expression levels of AK4 in control or AK4 ablation tumors isolated from mice. Results are presented as , .

(a)

(b)

(c)