Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection

Table 3

Association of IFNG and IFNGR1 polymorphisms with different groups.

Genes/SNPs	Genetic model	LTBI vs. PTB		HCS vs. LTBI		IGRA (+) vs. IGRA (-)
		^#	OR (95%CI)^#	^#	OR (95%CI)^#	^#	OR (95%CI)^#
IFNG
rs1861494	Allelic	0.440	1.14 (0.80-1.57)	0.166	0.80 (0.58-1.10)	0.428	0.61 (0.18-2.08)
T>C	Dominant	0.627	1.11 (0.72-1.72)	0.573	0.89 (0.58-1.35)	0.675	0.70 (0.13-3.76)
	Recessive	0.368	1.40 (0.68-2.89)	0.046	0.50 (0.25-0.99)	0.188	0.15 (0.01-2.50)
rs2069718
A>G	Allelic	0.477	0.86 (0.56-1.32)	0.194	1.33 (0.87-2.03)	0.689	1.56 (0.18-13.64)
	Dominant	0.601	0.88 (0.54-1.43)	0.368	1.25 (0.77-2.01)	0.733	1.49 (0.15-14.87)
	Recessive	0.439	0.58 (0.15-2.30)	0.113	3.76 (0.73-19.28)	—
IFNGR1
rs1327475	Allelic	0.075	1.56 (0.96-2.54)	0.159	0.71 (0.44-1.14)	0.390	0.47 (0.09-2.62)
G>A	Dominant	0.070	1.63 (0.96-2.75)	0.131	0.68 (0.41-1.13)	0.360	0.40 (0.06-2.82)
	Recessive	—		—		—
rs2234711
G>A	Allelic	0.360	0.87 (0.64-1.18)	0.055	1.35 (0.99-1.83)	0.520	1.49 (0.45-4.95)
	Dominant	0.306	0.79 (0.50-1.24)	0.047	1.55 (1.00-2.40)	0.972	1.03 0.17-6.27)
	Recessive	0.694	0.89 (0.50-1.58)	0.335	1.33 (0.75-2.35)	—
rs3799488
T>C	Allelic	0.368	0.85 (0.60-1.21)	0.471	0.89 (0.64-1.23)	0.536	0.68 (0.20-2.30)
	Dominant	0.212	0.76 (0.49-1.17)	0.674	0.91 (0.60-1.39)	0.214	0.32 (0.05-1.93)
	Recessive	0.761	1.16 (0.44-3.03)	0.325	0.65 (0.27-1.54)	—
rs9376267
C>T	Allelic	0.987	0.99 (0.74-1.35)	0.175	0.81 (0.61-1.10)	0.884	0.92 (0.29-2.90)
	Dominant	0.437	1.21 (0.75-1.95)	0.157	0.71 (0.44-1.14)	0.538	0.49 (0.05-4.70)
	Recessive	0.374	0.79 (0.46-1.34)	0.443	0.83 (0.51-1.35)	0.683	1.61 (0.16-15.96)

SNPs: single-nucleotide polymorphisms; CI: confidence interval; OR: odds ratio; PTB: pulmonary tuberculosis; LTBI: latent tuberculosis infection; HCS: healthy control subjects; IGRA: interferon gamma release assay. ^#Adjusted by age and sex status, in pulmonary tuberculosis group, +/- positive/negative.