Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease

Figure 1

Patients with ischemic heart disease (IHD) have low level of intestinal alkaline phosphatase (IAP) in their stool. Stool samples of control healthy participants and IHD patients were homogenized in a stool dilution buffer followed by centrifugation and collection of supernatant. The supernatant was assayed for IAP concentration using an automatic biochemistry analyzer. Statistics: values are expressed as . Statistical significance of the difference between two groups was tested using the unpaired two-tailed Student’s -test. is considered significant. , . The post hoc statistical power of the study was 99.6%, validating the adequacy of power (conventionally, >80% power at ) for sample sizes. Percentage of IAP in IHD patients compared to healthy controls: total, 70.5%; male, 79.9%; female, 72.9%. The average IAP level is 20.7% less in healthy control males compared to healthy females; however, the difference is not significant (). The average IAP level is 13.0% less in IHD males compared to IHD females; however, the difference is not significant ().