Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease

Table 5

Multiple logistic regression analysis predicts an association of intestinal alkaline phosphatase (IAP) deficiency with ischemic heart disease (IHD).

Explanatory variables	Logistic coefficient per unit change	Odds ratio (95% CI)
IAP (U/g stool)	-0.00730	0.993 (0.987-0.998)
Sex (ref = male)	-0.3759	0.471 (0.288-0.771)
Age (yr.)	0.0284	1.029 (1.001-1.057)
Body mass index (BMI, kg/m^2)	-0.00894	0.991 (0.936-1.050)
Creatinine (mmol/l)	0.0364	1.037 (1.025-1.049)
Total cholesterol (mg/dl)	0.00114	1.001 (0.983-1.020)
HDL-cholesterol (mg/dl)	-0.0362	0.964 (0.930-1.000)
LDL-cholesterol (mg/dl)	0.0127	1.013 (0.994-1.032)
Triglycerides (mg/dl)	0.000809	1.001 (0.997-1.005)
ALT (U/l)	0.0110	1.011 (1.003-1.019)
Systolic blood pressure (mmHg)	-0.0746	0.928 (0.911-0.945)
Diastolic blood pressure (mmHg)	0.0660	1.068 (1.039-1.098)
FPG (mmol/l)	0.4717	1.603 (1.339-1.918)
Area under the

Multiple logistic regression analysis reveals that the IAP level is negatively associated with log-odds of IHD. For one unit (U/g stool) increase in the IAP level, the odds of developing IHD is decreased by 1% controlling for other risk factors, which indicates that high IAP level is probably protective against IHD. Statistics: Proc Logist procedure (SAS) was used for multiple logistic regression analysis determining association between IHD and independent risk factors (explanatory variables) including IAP. is considered significant. ; ; .