Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients?
Table 1
Clinical characteristics of the study patients depending on the cut-off obtained for AKI prediction.
<178 μg/L
≥178 μg/L
value
55
45
—
Age (years)
0.009
Male
37 (67)
23 (51)
0.075
Characteristics at ICU admission
SAPS II
0.095
APACHE II
0.059
SOFA
<0.0001
AKI admission (%)
6 (10.9)
27 (15.6)
<0.0001
KDIGO stage 3 at admission (%)
2 (3.6)
12 (26.7)
0.001
RRT admission (%)
2 (3.6)
3 (6.7)
0.400
Creatinine clearance (mL/min)
<0.0001
Cockcroft–Gault
<0.0001
Characteristics during ICU stay
Mechanical ventilation (%)
46 (82)
36 (80)
0.410
Vasopressor requirement (%)
6 (11)
22 (49)
<0.0001
ICU length of stay (days)
0.360
ICU mortality (%)
10 (18.2)
12 (26.7)
0.210
Sepsis
3 (5.5)
26 (57.8)
0.007
Septic shock
2 (3.6)
18 (40)
<0.0001
AKI development (%)
2 (3.6)
6 (13.3)
0.070
KDIGO stage 3 development (%)
2 (3.6)
16 (35.6)
<0.0001
RRT after admission (%)
0 (0)
4 (8.9)
0.038
RRT total (%)
2 (3.6)
7 (15.6)
0.040
Values expressed as either % per column or deviation. : value of statistical significance. SAPS II: Simplified Acute Physiology Score II; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA: Sequential Organ Failure Assessment score; AKI: acute kidney injury; KDIGO: Improving Global Outcomes AKI group classification; RRT: Renal replacement therapies; ICU: intensive care unit.
