MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions

Figure 1

MicroRNAs are differentially expressed in MPM PE cells. (a) Volcano plot of significantly up- (red dots) and downregulated (green dots) microRNA in MPM vs. other diseases (adenocarcinoma and benign diseases combined) as determined by TaqMan OpenArray profiling. (b) Expression of the top differentially expressed microRNA between MPM and other PE-causing diseases as validated by RT-qPCR. MicroRNA expression was normalised to RNU44 and 48, expressed as 2^–ΔCT, and plotted on a logarithmic scale. The line within the boxes represents the median values, and the top and bottom of the boxes indicate the interquartile ranges. The whiskers demonstrate the upper and lower adjacent values for each disease group (, ).

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