Role of Plasma Calreticulin in the Prediction of Severity in Septic Patients
Table 3
Cox proportional hazards models for mortality prediction based on calreticulin levels and severity scores.
Variable
Univariate Cox model
value
Multivariate Cox model
value
HR (95% CI)
HR (95% CI)
Heart rate
1.016 (1.000-1.033)
0.051
0.979 (0.957-1.000)
0.052
Respiration rate
1.098 (1.038-1.160)
0.001
1.141 (1.057-1.233)
0.001
MAP
0.972 (0.951-0.994)
0.014
1.001 (0.974-1.028)
0.960
PaO2/FiO2
0.993 (0.988-0.998)
0.003
0.997 (0.992-1.002)
0.207
APACHE II score
1.105 (1.061-1.151)
0.0001
1.070 (1.014-1.129)
0.013
WBC
1.042 (1.012-1.073)
0.006
0.904 (0.631-1.296)
0.584
PMN
1.052 (1.019-1.086)
0.002
1.194 (0.806-1.769)
0.377
Lactate
1.333 (1.194-1.489)
0.0001
1.204 (0.990-1.463)
0.063
PCT
1.003 (0.996-1.010)
0.433
NA
NA
Calreticulin
1.017 (1.002-1.031)
0.022
1.103 (0.991-1.034)
0.246
values less than 0.05 were considered statistically significant. APACHE: Acute Physiology and Chronic Health Evaluation; CI: confidence interval; FiO2: inspiratory oxygen fraction; HR: hazard ratio; NA: not applicable; PaO2: arterial oxygen tension; PCT: procalcitonin; WBC: white blood cell; PMN: neutrophil; MAP: mean arterial pressure.
