Integrated Microfluidic Device for Enrichment and Identification of Circulating Tumor Cells from the Blood of Patients with Colorectal Cancer

Figure 1

Schematic drawing of the integrated microfluidic device for CTC enrichment and analysis. (a) Layout of the integrated microfluidic device. It was composed of four layers, in which the top layer was a gas control layer containing microvalve and micropump channels. The two middle layers were fluidic microchannels, and the bottom layer contained microfeatures leading to multiple-cell trapping chambers with individual pore channels. (b) Photograph of the prototype microfluidic device. (c) A schematic representing how larger cancer cells got trapped in the trapping chamber while other blood cells with the smaller size escaped.

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