Increased Levels of Endothelin-1 in Cerebrospinal Fluid Are a Marker of Poor Visual Recovery after Optic Neuritis in Multiple Sclerosis Patients

Table 2

Mean (SD) concentrations of serum and CSF ET-1 (pg/ml) in patients with aggressive vs. nonaggressive MS-ON phenotype.

	A-MS-ON	NA-MS-ON
Median (IQR) serum ET-1: pg/ml	0.65 (0.49-0.81)	0.82 (0.59-1.17)	0.3059^a
Median (IQR) CSF ET-1: pg/ml	0.30 (0.22-0.55)	0.16 (0.05-0.23)	0.008^a
Median (IQR) CSF/serum ET-1 quotient	0.56 (0.34-0.68)	0.16 (0.06-0.33)	0.0034^a

^aMann-Whitney test for nonparametric data; A-MS-ON: aggressive optic neuritis in multiple sclerosis (see text for definition); CSF: cerebrospinal fluid; ET-1: endothelin-1; NA-MS-ON: nonaggressive optic neuritis in multiple sclerosis (see text for definition).