Research Article
Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm
Table 2
Association between the BET1L and H19 polymorphisms and IA risk.
| | Polymorphisms | Controls, (%) | Patients, (%) | Adjusted OR (95% CI)† | value |
| | BET1L rs2280543 | | | | | | CC | 455 (77.4) | 380 (70.1) | 1.00 | | | CT | 123 (20.9) | 147 (27.1) | 1.43 (1.08-1.90) | 0.01 | | CT/TT | 133 (22.6) | 162 (29.9) | 1.48 (1.12-1.94) | 0.005 | | Additive model | | | 1.40 (1.11-1.78) | 0.005 | | C allele | 1033 (87.8) | 907 (83.7) | 1.00 | | | T allele | 143 (12.2) | 177 (16.3) | 1.44 (1.13-1.83) | 0.003 | | H19 rs217727 | | | | | | CC | 238 (40.5) | 182 (33.6) | 1.00 | | | CT | 259 (44.0) | 230 (42.4) | 1.14 (0.87-1.49) | 0.36 | | TT | 91 (15.5) | 130 (24.0) | 1.90 (1.35-2.67) | <0.001 | | CT/TT | 350 (59.5) | 360 (66.4) | 1.33 (1.03-1.71) | 0.03 | | Additive model | | | 1.33 (1.13-1.56) | <0.001 | | C allele | 735 (62.5) | 594 (54.8) | 1.00 | | | T allele | 441 (37.5) | 490 (45.2) | 1.38 (1.16-1.64) | <0.001 | | H19 rs2839698 | | | | | | CC | 318 (54.1) | 312 (57.6) | 1.00 | | | CT | 221 (37.6) | 194 (35.8) | 0.90 (0.70-1.17) | 0.44 | | TT | 49 (8.3) | 36 (6.6) | 0.80 (0.50-1.27) | 0.33 | | CT/TT | 270 (45.9) | 230 (42.4) | 0.88 (0.69-1.13) | 0.32 | | Additive model | | | 0.88 (0.73-1.06) | 0.18 | | C allele | 857 (72.9) | 818 (75.5) | 1.00 | | | T allele | 319 (27.1) | 266 (24.5) | 0.89 (0.74-1.08) | 0.25 | | H19 rs2735971 | | | | | | GG | 413 (70.2) | 382 (70.5) | 1.00 | | | AG | 153 (26.0) | 130 (24.0) | 0.86 (0.65-1.14) | 0.30 | | AA | 22 (3.7) | 30 (5.5) | 1.54 (0.87-2.74) | 0.14 | | AG/AA | 175 (29.8) | 160 (29.5) | 0.95 (0.73-1.24) | 0.70 | | Additive model | | | 1.04 (0.85-1.28) | 0.68 | | G allele | 979 (83.2) | 894 (82.5) | 1.00 | | | A allele | 197 (16.8) | 190 (17.5) | 1.04 (0.83-1.30) | 0.74 |
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IA: intracranial aneurysm; OR: odds ratio; CI: confidence interval. †Adjusted by age, gender, and familial history of IA.
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