Research Article
Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm
Table 3
Stratification analyses by the number of aneurysms.
| | Polymorphisms | Multiple aneurysm, (%) | Single aneurysm, (%) | Adjusted OR (95% CI)† | value |
| | BET1L rs2280543 | | | | | | CC | 59 (79.7) | 321 (68.6) | 1.00 | | | CT/TT | 15 (20.3) | 147 (31.4) | 0.56 (0.31-1.02) | 0.05 | | C allele | 130 (87.8) | 777 (83.0) | 1.00 | | | T allele | 18 (12.2) | 159 (17.0) | 0.68 (0.40-1.14) | 0.13 | | H19 rs217727 | | | | | | CC | 20 (27.0) | 162 (34.6) | 1.00 | | | CT/TT | 54 (73.0) | 306 (65.4) | 1.37 (0.79-2.38) | 0.25 | | C allele | 72 (48.6) | 522 (55.8) | 1.00 | | | T allele | 76 (51.4) | 414 (44.2) | 1.28 (0.91-1.82) | 0.16 | | H19 rs2839698 | | | | | | CC | 46 (62.2) | 266 (56.8) | 1.00 | | | CT/TT | 28 (37.8) | 202 (43.2) | 0.79 (0.48-1.31) | 0.36 | | C allele | 115 (77.7) | 703 (75.1) | 1.00 | | | T allele | 33 (22.3) | 233 (24.9) | 0.85 (0.56-1.29) | 0.45 | | H19 rs2735971 | | | | | | GG | 53 (71.6) | 329 (70.3) | 1.00 | | | AG/AA | 21 (28.4) | 139 (29.7) | 0.95 (0.55-1.64) | 0.85 | | G allele | 123 (83.1) | 771 (82.4) | 1.00 | | | A allele | 25 (16.9) | 165 (17.6) | 0.94 (0.59-1.49) | 0.79 |
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IA: intracranial aneurysm; OR: odds ratio; CI: confidence interval. †Adjusted by age, gender, and familial history of IA.
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