Research Article
Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm
Table 4
Stratification analyses by ruptured aneurysm (yes vs. no).
| | Polymorphisms | Ruptured aneurysm | Adjusted OR (95% CI)† | value | | Yes, (%) | No, (%) |
| | BET1L rs2280543 | | | | | | CC | 333 (69.8) | 47 (72.3) | 1.00 | | | CT/TT | 144 (30.2) | 18 (27.7) | 0.88 (0.49-1.56) | 0.65 | | C allele | 797 (83.5) | 110 (84.6) | 1.00 | | | T allele | 157 (16.5) | 20 (15.4) | 0.91 (0.55-1.52) | 0.72 | | H19 rs217727 | | | | | | CC | 160 (33.5) | 22 (33.8) | 1.00 | | | CT/TT | 317 (66.5) | 43 (66.2) | 1.05 (0.60-1.82) | 0.87 | | C allele | 522 (54.7) | 72 (55.4) | 1.00 | | | T allele | 432 (45.3) | 58 (44.6) | 1.01 (0.70-1.47) | 0.94 | | H19 rs2839698 | | | | | | CC | 270 (56.6) | 42 (64.6) | 1.00 | | | CT/TT | 207 (43.4) | 23 (35.4) | 0.71 (0.41-1.21) | 0.20 | | C allele | 714 (74.8) | 104 (80.0) | 1.00 | | | T allele | 240 (25.2) | 26 (20.0) | 0.74 (0.47-1.16) | 0.18 | | H19 rs2735971 | | | | | | GG | 335 (70.2) | 47 (72.3) | 1.00 | | | AG/AA | 142 (29.8) | 18 (27.7) | 0.92 (0.51-1.64) | 0.77 | | G allele | 787 (82.5) | 107 (82.3) | 1.00 | | | A allele | 167 (17.5) | 23 (17.7) | 1.04 (0.64-1.68) | 0.88 |
|
|
IA: intracranial aneurysm; OR: odds ratio; CI: confidence interval. †Adjusted by age, gender, and familial history of IA.
|
