Replication of GWAS Loci Revealed an Increased Risk of BET1L and H19 Polymorphisms with Intracranial Aneurysm

Table 5

Combined analyses of the BET1L and H19 polymorphisms with IA risk.

Combined genotypes	Controls (%)	IA (%)	OR (95% CI)	value
BET1L rs2280543-H19 rs217727
rs2280543 CC-rs217727 CC	238 (40.5)	121 (22.3)	1.00
rs2280543 CC-rs217727 CT/TT	217 (36.9)	259 (47.8)	2.35 (1.77-3.12)	<0.001
rs2280543 CT/TT-rs217727 CC	—	61 (11.3)	—	—
rs2280543 CT/TT-rs217727 CT/TT	133 (22.6)	101 (18.6)	1.49 (1.06-2.10)	0.02
BET1L rs2280543-H19 rs2839698
rs2280543 CC-rs2839698 CC	237 (40.3)	219 (40.4)	1.00
rs2280543 CC-rs2839698 CT/TT	218 (37.1)	161 (29.7)	0.80 (0.61-1.05)	0.11
rs2280543 CT/TT-rs2839698 CC	81 (13.8)	93 (17.2)	1.24 (0.88-1.76)	0.22
rs2280543 CT/TT-rs2839698 CT/TT	52 (8.8)	69 (12.7)	1.44 (0.96-2.15)	0.08
BET1L rs2280543-H19 rs2735971
rs2280543 CC-rs2735971 GG	325 (55.3)	265 (48.9)	1.00
rs2280543 CC-rs2735971 AG/AA	130 (22.1)	115 (21.2)	1.09 (0.81-1.46)	0.59
rs2280543 CT/TT-rs2735971 GG	88 (15.0)	117 (21.6)	1.63 (1.18-2.25)	0.003
rs2280543 CT/TT-rs2735971 AG/AA	45 (7.7)	45 (8.3)	1.23 (0.79-1.91)	0.37
H19 rs217727-H19 rs2839698
rs217727 CC-rs2839698 CC	128 (21.8)	105 (19.4)	1.00
rs217727 CC-rs2839698 CT/TT	110 (18.7)	77 (14.2)	0.85 (0.58-1.26)	0.42
rs217727 CT/TT-rs2839698 CC	190 (32.3)	207 (38.2)	1.33 (0.96-1.84)	0.09
rs217727 CT/TT-rs2839698 CT/TT	160 (27.2)	153 (28.2)	1.17 (0.83-1.64)	0.38
H19 rs217727-H19 rs2735971
rs217727 CC-rs2735971 GG	175 (29.8)	128 (23.6)	1.00
rs217727 CC-rs2735971 AG/AA	63 (10.7)	54 (10.0)	1.17 (0.76-1.80)	0.47
rs217727 CT/TT-rs2735971 GG	238 (40.5)	254 (46.9)	1.46 (1.09-1.95)	0.01
rs217727 CT/TT-rs2735971 AG/GG	112 (19.0)	106 (19.6)	1.29 (0.91-1.84)	0.15

IA: intracranial aneurysm; OR: odds ratio; CI: confidence interval.