Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis

Table 3

Distributions of allele and genotype frequencies in the study sample.

SNP	Group	Allele			P-Allele	Genotype				P-Genotype	P-HWE
		G	A			GG	GA	AA
rs3755955	Fracture	264 (76.7%)	80 (23.3%)	1	0.709	105 (61.0%)	54 (31.4%)	13 (7.6%)	2	0.902
	Control	244 (78.2%)	68 (21.8%)			98 (62.8%)	48 (30.8%)	10 (6.4%)			0.224
	Total	508 (77.4%)	148 (22.6%)			203 (61.9%)	102 (31.1%)	23 (7.0%)
		G	A			GG	GA	AA
rs6831280	Fracture	254 (73.8%)	90 (26.2%)	1	0.002	95 (55.2%)	64 (37.2%)	13 (7.6%)	2	0.012
	Control	264 (83.5%)	52 (16.5%)			111 (70.2%)	42 (26.6%)	5 (3.2%)			0.676
	Total	518 (78.5%)	131 (21.5%)			206 (62.4%)	106 (32.1%)	18 (5.5%)
		A	C			AA	AC	CC
rs28377268	Fracture	73 (21.2%)	271 (78.8%)	1	0.924	9 (5.2%)	55 (32.0%)	108 (62.8%)	2	0.992
	Control	65 (20.8%)	247 (79.2%)			8 (5.1%)	49 (31.4%)	99 (63.5%)			0.551
	Total	138 (21.0%)	518 (79.0%)			17 (5.2%)	104 (31.7%)	207 (63.1%)