Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis

Table 5

Associations of SNPs genotyped with BTMs and BMDs in participants with OP.

Variable	Rs3755955				Rs6831280				Rs28377268
	CC	CT	TT		GG	GA	AA		AA	AC	CC
β-CTX (ng/ml)				0.44				0.177				0.914
PINP (ng/ml)				0.285			47.100+ 25.738	0.392				0.44
BMD-L2-4 (g/cm^2)				0.448				0.004				0.837
BMD-FN (g/cm^2)				0.893				0.549				0.724
BMD-WT (g/cm^2)				0.758				0.256				0.413
BMD-FT (g/cm^2)				0.786				0.053				0.653
BMD-TH (g/cm^2)				0.711				0.027^#				0.915

β-CTX: procollagen type I carboxy terminal peptide beta special sequence; PINP: procollagen I N-terminal propeptide; BMD: bone mineral density; L2-4: L2-4 vertebra; FN: femoral neck; WT: Ward’s triangle; FT: femoral trochanter; TH: total hip. All values were adjusted for age and BMI by ANCOVA. GG vs. GA , GG vs. AA , and GA vs. AA by post hoc Bonferroni test. ^#GG vs. GA , GG vs. AA , and GA vs. AA by post hoc Bonferroni test.