Disease Markers

Research Article

Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration

Table 5

Binomial logistic regression analysis of the CFI rs10033900, ERCC6 rs3793784, VEGFA rs833068, HTRA1 rs11200638, TIMP3 rs9621532, and KCTD10 rs56209061 SNPs in the exudative AMD and control groups.


Exudative AMD
SNP	Model/genotype/allele	OR; 95% CI;	AIC

	Codominant
rs3793784	GC vs. GG	0.889; 0.618-1.279; 0.526	780.990
rs3793784	CC vs. GG	2.271; 1.333-3.870; 0.003	780.990

rs11200638	GA vs. GG	2.603; 1.761-3.846; <0.001	718.588
rs11200638	AA vs. GG	8.683; 5.090-14.810; <0.001	718.588

	Dominant
rs11200638	GA+AA vs. GG	3.701; 2.569-5.332; <0.001	739.869

	Recessive
rs3793784	CC vs. GC+GG	2.427; 1.483-3.970; <0.001	779.392
rs11200638	AA vs. GA+GG	5.146; 3.174-8.344; <0.001	740.394

	Additive
rs11200638	A	2.876; 2.230-3.709; <0.001	716.992
rs56209061	A	0.583; 0.394-0.863; 0.007	785.038

was adjusted for age in logistic regression models. OR: odds ratio; 95% CI: 95% confidence interval; values < 0.008 indicated in bold are statistically significant; AIC: Akaike information criterion.