Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis

Table 2

Summary of the results of meta-analysis.

Group-wise	No. of studies	No. of subjects		Meta-analysis				Heterogeneity			Egger’s bias
				Hedges’	95% CI		value	(%)	Tau^2	value	value
Total
SLE vs. HC (including KPS data)	12	SLE 662	HC 771	2.104	1.426	2.782	<0.001	96.046	1.308	<0.001	0.02
SLE vs. HC (excluding KPS data)	11	SLE 651	HC 762	1.963	1.276	2.650	<0.001	96.217	1.256	<0.001	0.02
Sex
Male vs. female SLE	2	Male 6	Female 26	0.360	-0.491	1.212	0.407	0.000	0.000	0.369	—
Renal manifestation
SLE with vs. without nephritis	3	With 53	Without 39	0.639	0.221	1.057	0.003	0.000	0.000	0.841	—
SLE with vs. without proteinuria	2	With 57	Without 82	1.535	0.207	2.862	0.023	79.694	0.751	0.023	—
Disease activity
SLE (+) vs. (-) anti-dsDNA	2	(+) 57	(-) 82	0.094	-1.352	1.540	0.898	83.360	0.924	0.014	—

Abbreviations used: dsDNA: double-stranded DNA antibodies; HC: healthy controls; SLE: systemic lupus erythematosus. values were all two-tailed.