Tissue Infiltrating Immune Cells as Prognostic Biomarkers in Endometrial Cancer: A Meta-Analysis

Table 1

Characteristics of eligible studies.

Author (year)	Ethnicity		Cell type	Age (year)	Follow-up	Tumour type, FIGO stage	Threshold for positive score	Localisation	Score
Salvesen (1999) [7]	European	60	CD68^+ TAM	≤66 : 29, >66 : 31	Median, 11 y (8-15)	EC, I-IV	Median, 33 cell/high-power field (HPF)	Hotspot	7
Ohno (2004) [17]	Asian	70	CD68^+ TAM	Mean, 57.3 (26-78)	Median, 3.28 y (0.15-8.5)	EC, I-IV	Median, nest TAM: 10.7; hotspot TAM: 12.1; stroma TAM, 19.1; margin TAM, 19.3	Hotspot, nest, margin, stroma	7
Giatromanolaki (2008) [26]	European	79	FoxP3^+ T cell	—	Median, 69 m (6-182)	EEC, I	3–8 cells/×100 optical field	Stroma	6
Soeda (2008) [8]	Asian	76	CD68^+ TAM	Mean, 55.9 (27-80)	Mean, 82 m (13-130)	EC, I-III	≥20	Margin	5
Ino (2008) [18]	Asian	65	CD8^+ T cell	Mean, 57.7	Median, 72 m (5-148)	EEC, I-IV	Intraepithelial: CD8^+ T ; stromal: CD8^+	(a) Intraepithelial; (b) Stromal or margin	5
de Jong (2009 [25], 2012 [24]), Versluis (2015) [28], Versluis (2017) [27]	European	368	CD8^+ T cell CD45RO^+ T cell	Median, 65 (32-89)	Median 6.2 y (2.4-10.5)	EC, I-IV	CD8^+ T cells/0.283 mm^2, CD45RO^+ T cell: absent	Intratumour	7
Jiang (2012, 2013) [4, 5]	Asian	186	CD68^+ TAM	Mean, 58.3 (21-84)	Mean, 76.3 m (5-151)	EEC, I-IV	Mean	2012: margin; 2013: the entire tumour region	7
Kubler (2014) [6]	European	163	CD163^+ TAM FoxP3^+ T cell	Median, (41-95)	Median, 7.92 y (6.92-8.92)	EC, I-IV	Median	Tumour nest	5
Ohnishi (2016) [23]	Asian	79	CD8 T cell	Mean, 59 (30-74)	—	EC, I-IV	≥120 cells/0.028 mm^2/HPF	Tumour nest	6
Workel (2016) [22]	European	305	CD8 T cell	≤60 : 118, >60 : 187	—	EC, I-IV	>4 cells/0.283 mm^2	Tumour nest	6
Rashid (2017) [21]	AA; EA	110	FoxP3^+ T cell CD45RO^+ T cell CD8^+ T cell	Median, AA : 61.46, EA : 63.55	Mean, AA : 44.74 m, EA : 59.02 m	—	FoxP3^+ T cell &CD8^+ T ; CD45RO^+ T	Tumour stroma	6
Yamashita (2018) [19]	Asian	149	CD8 T cell	<60 : 76, ≥60 : 73	Median, 38 m (1-134)	EC, I-IV	>30% staining	The entire tumour region	6
Kim (2018) [20]	Asian	183	CD8 T cell	Mean,	Median, 30.3	EC, I-IV	>21 cells/0.237 mm^2/HPF	Center of tumour	7

TAM = tumour-associated macrophage; EC = endometrial carcinoma; EEC = endometrial endometrioid carcinoma; y = year; m = month; score = NOS score; AA = African America; EA = European American. Data from studies of the same populations were only extracted once.