Tissue Infiltrating Immune Cells as Prognostic Biomarkers in Endometrial Cancer: A Meta-Analysis

Table 3

Subgroup analysis of immune cells and prognostic indices in EC patients.

Group	Subgroup	Study number	Number of case	Pooled result, HR (95% CI)	PZ value	PH value
CD8-OS	Intraepithelial	3	630	0.320 (0.120-0.849)	0.002	0.265	24.8%
	Stromal	1	110	0.064 (0.016-0.253)	0.001	0.915	0.0%
	Whole^#	1	149	0.850 (0.070-10.560)	0.899	—	—
CD8-PFS	Intraepithelial	2	248	0.262 (0.111-0.621)	0.002	0.612	0.0%
	Stromal	1	65	0.460 (0.040-5.220)	0.532	—	—
	Whole^#	1	149	0.790 (0.100-6.440)	0.824	—	—
FoxP3^+ T cell-OS	Intraepithelial	1	163	1.000 (1.000-1.000)	0.678	—	—
	Stromal	2	189	1.264 (0.419-3.812)	0.678	0.212	35.6%
FoxP3^+ T cell-RFS	Intraepithelial	1	163	1.000 (1000-1.010)	1.000	—	—
	Stromal	1	110	1.103 (0.516-2.360)	0.801	0.377	0.0%
CD45RO^+ T cell-OS	Intraepithelial	1	368	0.490 (0.260-0.950)	0.031	—	—
	Stromal	1	110	0.280 (0.103-0.757)	0.012	0.833	0.0%
TAM-OS	CD68^+ TAM	2	262	3.219 (0.740-13.998)	0.119	0.637	0.0%
	CD163^+ TAM	1	163	1.400 (0.410-4.860)	0.586	—	—
	FIGO stage I-III	1	76	1.810 (0.109-29.996)	0.679	—	—
	FIGO stage I-IV	2	349	2.008 (0.735-5.487)	0.174	0.336	0.0%
TAM-RFS-c/d	Intraepithelial	3	293	3.582 (0.889-14.264)/1.397 (0.260-7.508)	0.070/0.696	0.210/0.052	36%/66.2%
	Stromal	1	186	4.200 (1.900–99.800)	0.156	—	—
	CD68^+ TAM	3	316	2.627 (0.858-8.049)/1.104 (0.293-4.156)	0.091/0.883	0.343/0.159	6.5%/45.7%
	CD163^+ TAM	1	163	8.310 (1.030-67.300)	0.035	—	—
TAM-RFS-e/f	Intraepithelial	2	223	2.836 (0.431-18.676)	0.278	0.127	57.0%
	Stromal	2	256	2.277 (0.665-7.792)/2.056 (0.651-6.494)	0.179/0.219	0.439/0.385	0.0%
	CD68^+ TAM	3	316	1.766 (0.679-4.590)/1.689 (0.676-4.222)	0.243/0.262	0.603/0.588	0.0%
	CD163^+ TAM	1	163	8.310 (1.030-67.300)	0.035	—	—

PZ: value of the -test; PH: value of the heterogeneity test. One study included two groups. ^#Study calculated immune cells in the whole tumour tissue.