High Plasma Levels of Soluble Talin-1 in Patients with Coronary Artery Disease
Table 1
Clinical characteristics and plasma sTalin-1 levels of patients with and without CAD.
CAD(-) ()
value
CAD ()
1-VD ()
2-VD ()
3-VD ()
value among 4 groups
CAD(-) vs. CAD
Age (years)
<0.001
<0.001
Gender (male)
95 (61%)
<0.01
145 (75%)
64 (73%)
43 (72%)
38 (83%)
<0.05
BMI (kg/m2)
NS
NS
Hypertension
93 (60%)
<0.001
151 (78%)
66 (75%)
46 (77%)
39 (85%)
<0.005
SBP (mmHg)
<0.05
<0.02
Diabetes mellitus
24 (15%)
<0.001
66 (34%)
25 (28%)
23 (38%)
18 (39%)
<0.001
HbA1c (%)
<0.001
<0.005
Smoking
45 (29%)
NS
77 (40%)
38 (43%)
25 (42%)
14 (30%)
NS
Hyperlipidemia
67 (43%)
<0.01
113 (58%)
51 (58%)
35 (58%)
27 (59%)
NS
Statin
42 (27%)
<0.001
87 (45%)
39 (44%)
26 (43%)
22 (48%)
<0.01
LDL-C (mg/dL)
NS
NS
HDL-C (mg/dL)
<0.001
<0.001
<40 mg/dL
14 (9%)
<0.05
34 (18%)
11 (13%)
11 (18%)
12 (26%)
<0.025
hsCRP (mg/L)
0.42 [0.21, 0.88]
<0.001
0.58 [0.33, 1.40]
0.59 [0.31, 1.35]
0.56 [0.30, 1.14]
0.70 [0.42, 2.03]
<0.002
>1.0 mg/L
35 (23%)
NS
63 (32%)
26 (30%)
19 (32%)
18 (39%)
NS
sTalin-1 levels (ng/mL)
0.23 [0.09, 0.44]
<0.005
0.30 [0.13, 0.66]
0.29 [0.12, 0.56]
0.30 [0.18, 0.72]
0.32 [0.11, 0.60]
<0.05
>0.28 ng/mL
56 (36%)
<0.005
104 (54%)
45 (51%)
32 (53%)
27 (59%)
<0.025
Data represent the or the number (%) of patients, with the exception of hsCRP and sTalin-1 levels which are presented as the median value and interquartile range. BMI indicates body mass index; SBP: systolic blood pressure; LDL-C: low-density lipoprotein cholesterol; and HDL-C: high-density lipoprotein cholesterol.
