Disease Markers / 2020 / Article / Tab 4

Research Article

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

Table 4

Univariate and multivariate analysis of FEN1 associated with OS and RFS in TCGA HCC cohort.

Univariate analysisMultivariate analysis
OS (%)HR95% CI valueHR95% CI value

Univariate and multivariate analyses of overall survival in HCC patients ()
Age<Medium ()116 (72.1%)0.8220.580–1.1650.270
≥Medium ()112(67.1%)
GenderFemale ()67 (63.8%)1.1170.936-1.3340.220
Male ()161(72.2%)
RaceOthers ()122 (72.2%)1.4540.800-2.6420.220
White ()106 (66.7%)
TNM stageStage I/II ()187 (76.3%)2.4831.713-3.600<0.0012.2711.544-3.339<0.001
Stage III/IV ()41 (49.4%)
AFP expressionLow ()115 (73.3%)0.8590.608-1.2150.391
High ()113 (66.1%)
FEN1 expressionLow ()124 (76.1%)1.6061.133-2.2770.0081.3780.935-2.0290.105
High ()104 (63.0%)

Univariate and multivariate analyses of relapse-free survival in HCC patients ()
Age<Medium ()116 (72.1%)0.9650.845-1.1020.601
≥Medium ()112 (67.1%)
GenderFemale ()67 (63.8%)1.0530.916-1.2090.468
Male ()161(72.2%)
RaceOthers ()122 (72.2%)0.8650.638-1.1740.352
White ()106 (66.7%)
TNM stageStage I/II ()187 (76.3%)2.0661.538-2.775<0.0011.8831.388-2.556<0.001
Stage III/IV ()41 (49.4%)
AFP expressionLow ()115 (73.3%)0.8460.650-1.1020.215
High ()113 (66.1%)
FEN1 expressionLow ()124 (76.1%)1.5931.221-2.0780.0011.3871.043-1.8450.025
High ()104 (63.0%)

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