Plasma-Derived Exosomal Circular RNA hsa_circ_0005540 as a Novel Diagnostic Biomarker for Coronary Artery Disease

Figure 1

Differentially expressed exosomal circRNAs between CAD patients and non-CAD controls. (a) Hierarchical clustering analysis of exosomal circRNA profile in CAD patients () and non-CAD controls (). The expression of exosomal circRNAs is hierarchically clustered on the -axis; CAD patients and non-CAD controls are hierarchically clustered on the -axis. Expression values are presented in red and blue to indicate upregulation and downregulation, respectively. (b) Volcano plot: -axis: log₂(fold change); -axis: -log₁₀( value). The red points indicate exosomal circRNAs 1.5-fold upregulated significantly and the green points represent exosomal circRNAs 1.5-fold downregulated with statistical significance.

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