Research Article
Abnormal PTBP1 Expression Sustains the Disease Progression of Multiple Myeloma
Figure 3
PTBP1 is linked to disease relapse in MM. (a) The expression of PTBP1 was significantly upregulated in relapsed patients from TT2 and TT3 cohorts in comparison with baseline patients. (b) The expression of PTBP1 was significantly upregulated in relapsed patients from the GSE83503 cohort in comparison with patients without relapse. (c) Bar view presents response rate between PTBP1low MM patients and PTBP1high MM patients treated with bortezomib. (d) Western blots showing the expression of PTBP1, PKM2, and GAPDH in 8226 and 8226-DR cells. (e) The expression of PTBP1 is showed in 12 MM patient samples collected at diagnosis, pre-1st and pre-2nd ASCT. (f) Kaplan-Meier analyses of OS revealed that high PTBP1 expression conferred inferior clinical outcomes in TT6 patients.
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