Novel Value of Preoperative Gamma-Glutamyltransferase Levels in the Prognosis of AFP-Negative Hepatocellular Carcinoma

Table 2

Univariate analysis of risk factors for overall survival and disease-free survival.

Variables	OS		DFS
	HR (95% CI)		HR (95% CI)
Age (y)
≤50	Reference		Reference
>50	1.19 (0.88-1.61)	0.251	1.09 (0.87-1.37)	0.458
Gender
Female	Reference		Reference
Male	1.03 (0.60-1.78)	0.905	0.83 (0.53-1.30)	0.415
Etiology
Other	Reference		Reference
HBV/HCV	1.37 (0.85-2.21)	0.192	1.91 (1.28-2.85)	0.002
PLT (10^9/L)
>100	Reference		Reference
≤100	1.35 (0.88-2.05)	0.166	1.28 (0.92-1.79)	0.149
ALT (U/L)
≤40	Reference		Reference
>40	1.37 (1.03-1.83)	0.032	1.47 (1.18-1.84)	0.001
TBIL (μmol/L)
≤17.2	Reference		Reference
>17.2	1.39 (1.00-1.90)	0.044	1.19 (0.93-1.53)	0.174
Albumin (g/L)
>35	Reference		Reference
≤35	3.45 (1.70-7.02)	0.001	0.84 (0.31-2.24)	0.720
GGT (U/L)
≤37.2	Reference		Reference
37.2-102.8	1.94 (1.29-2.91)	0.001	1.82 (1.37-2.42)	<0.001
≥102.8	3.92 (2.57-5.99)	<0.001	2.53 (1.84-3.49)	<0.001
ALBI grade
1	Reference		Reference
2	1.92 (1.39-2.67)	<0.001	1.32 (1.00-1.75)	0.048
Liver cirrhosis
No	Reference		Reference
Yes	1.41 (1.04-1.92)	0.027	1.22 (0.97-1.54)	0.086
Tumor size, cm
≤5	Reference		Reference
>5	1.84 (1.37-2.47)	<0.001	1.61 (1.28-2.00)	<0.001
Tumor number
≤1	Reference		Reference
>1	3.20 (2.35-4.36)	<0.001	2.01 (1.59-2.72)	<0.001
MVI
Absent	Reference		Reference
Present	2.61 (1.86-3.67)	<0.001	1.96 (1.48-2.59)	<0.001

OS: overall survival; DFS: disease-free survival; PLT: platelet; ALT: alanine aminotransferase; TBIL: total bilirubin; GGT: gamma-glutamyltransferase; ALBI grade: albumin-bilirubin grade; MVI: microvascular invasion.