The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis

Table 2

Subgroup analysis and metaregression of the studies reporting the effect of F-NLR score in OS.

Stratified study	No. of studies	Pooled HR (95% CI)	Heterogeneity		Metaregression
			(%)	value	Tau^2	Adj (%)	value
Cancer type					0.04	-11.81	0.77
Digestive system	7	1.817 (1.497-2.206)	0	0.77
NSCLC	4	1.65 (1.266-2.15)	81.9	<0.01
Other type	1	2.103 (1.401-3.156)	—	—
Publication year					0.03	15.36	0.23
≥2017	7	1.683 (1.389-2.04)	69.3	<0.01
<2017	5	2.121 (1.598-2.817)	0	0.97
Sample size					0.03	29.73	0.11
	7	2.105 (1.684-2.631)	0	0.99
	5	1.618 (1.307-2.004)	76	<0.01
Country					0.03	8.8	0.36
China	7	1.715 (1.406-2.092)	71.6	<0.01
Japan	5	2.04 (1.531-2.718)	0	0.99
Analysis type					0.03	6.9	0.37
Multivariate	7	1.676 (1.371-2.049)	58.9	0.02
Univariate	5	1.909 (1.608-2.267)	0	0.43
Gender (Female, %)					0.02	44.22	0.1
>31	7	1.617 (1.35-1.937)	56.7	0.03
≤31	5	2.12 (1.739-2.585)	0	0.98
Age (year)					0.04	-12.82	0.61
>60	8	1.742 (1.389-2.184)	61.4	0.01
≤60	4	1.874 (1.445-2.432)	46.7	0.13