The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis

Table 3

Subgroup analysis and metaregression of the studies reporting the prognostic role of F-NLR score in DFS/PFS.

Stratified study	No. of studies	Pooled HR (95% CI)	Heterogeneity		Metaregression
			(%)	value	Tau^2	Adj (%)	value
Cancer type					0.13	-35.24	0.9
Digestive system	3	1.875 (1.133-3.102)	76.6	0.01
NSCLC	2	1.32 (1.076-1.619)	68.1	0.08
Other type	1	2.49 (1.618-3.832)	—	—
Publication year					0.04	63.11	0.1
≥2017	5	1.471 (1.22-1.773)	64.9	0.02
<2017	1	3.26 (1.909-5.567)	—	—
Sample size					0.01	93.11	0.03
	3	2.383 (1.659-3.422)	37.3	0.2
	3	1.334 (1.169-1.523)	39	0.19
Country					0.07	25.86	0.34
China	4	1.497 (1.182-1.896)	71.6	<0.01
Japan	1	1.65 (0.969-2.808)	—	—
Italy	1	2.49 (1.618-3.832)	—	—
Analysis type					0.07	21.85	0.21
Multivariate	2	1.32 (1.076-1.619)	68.1	0.08
Univariate	4	2.005 (1.327-3.031)	75.6	<0.01
Gender (female, %)					0.06	33.39	0.25
>31	4	1.46 (1.189-1.793)	72.6	0.01
≤31	2	2.318 (1.189-4.517)	68	0.08
Age (year)					0.06	30.42	0.16
>60	3	1.278 (1.12-1.459)	82.9	<0.01
≤60	3	2.181 (1.304-3.646)	5.8	0.34