Lack of Efficacy of Combined Carbohydrate Antigen Markers for Lung Cancer Diagnosis

Table 3

Compare the four panels of biomarkers in lung cancer diagnosis.

Panels	Sensitivity ( value)	Specificity ( value)	PPV ( value)	NPV ( value)	AUC ( value)
Panel 1 vs. panel 2	0.063	0.507	0.870	0.126	0.194 ()
Panel 1 vs. panel 3	<0.0001	0.073	0.988	<0.0001	0.039 ()
Panel 1 vs. panel 4	0.063	0.148	0.519	0.180	0.10 ()
Panel 2 vs. panel 3	<0.001	0.015	0.871	<0.0001	<0.0001 ()
Panel 2 vs. panel 4	1.000	0.432	0.625	0.878	0.387 ()
Panel 3 vs. panel 4	<0.001	0.001	0.557	<0.0001	<0.0001 ()

Panel = CYFR21, CEA, NSE, and SCC; panel 2 = CYFR21, CEA, NSE, SCC, CA125, and CA15-3; panel 3 = CA125, CA15-3, CA19-9, CA50, CA242, and CA724; panel 4 = CYFR21, CEA, NSE, SCC, CA125, CA15-3, CA19-9, CA50, CA242, and CA724.