Lack of Efficacy of Combined Carbohydrate Antigen Markers for Lung Cancer Diagnosis

Table 4

Performances of biomarkers in lung adenocarcinoma diagnosis.

Biomarkers	Sensitivity	Specificity	PPV	NPV	AUC (95% CI)
CYFR21	0.766	0.732	0.721	0.776	0.777 (0.693-0.862)
CEA	0.639	0.827	0.667	0.787	0.812 (0.734-0.890)
NSE	0.409	0.757	0.600	0.589	0.589 (0.485-0.694)
SCC	0.123	0.848	0.643	0.549	0.523 (0.415-0.630)
CA125	0.414	0.879	0.744	0.640	0.674 (0.575-0.773)
CA15-3	0.471	0.951	0.892	0.678	0.793 (0.710-0.876)
CA199	0.121	0.915	0.727	0.356	0.399 (0.293-0.505)
CA50	0.042	0.988	0.750	0.547	0.525 (0.420-0.630)
CA242	0.129	0.871	0.450	0.548	0.416 (0.312-0.519)
CA724	0.192	0.941	0.700	0.627	0.640 (0.541-0.740)
The panel 1	0.849	0.619	0.579	0.869	0.864 (0.787-0.922)
The panel 2	0.867	0.576	0.561	0.883	0.897 (0.826-0.946)
The panel 3	0.644	0.730	0.595	0.768	0.794 (0.708-0.864)
The panel 4	0.945	0.525	0.552	0.939	0.904 (0.834-0.951)