Lack of Efficacy of Combined Carbohydrate Antigen Markers for Lung Cancer Diagnosis

Table 5

Diagnostic efficacy of biomarkers with squamous-cell carcinoma.

Biomarkers	Sensitivity	Specificity	PPV	NPV	AUC (95% CI)
CYFR21	0.846	0.732	0.537	0.929	0.847 (0.749-0.945)
CEA	0.700	0.827	0.500	0.914	0.804 (0.702-0.905)
NSE	0.321	0.757	0.333	0.747	0.501 (0.350-0.651)
SCC	0.517	0.848	0.517	0.848	0.758 (0.646-0.870)
CA125	0.464	0.879	0.565	0.830	0.767 (0.661-0.874)
CA15-3	0.321	0.951	0.692	0.804	0.687 (0.559-0.816)
CA199	0.310	0.915	0.750	0.615	0.493 (0.357-0.630)
CA50	0.138	0.988	0.800	0.766	0.599 (0.463-0.735)
CA242	0.172	0.871	0.313	0.755	0.456 (0.322-0.590)
CA724	0.172	0.941	0.455	0.800	0.622 (0.490-0.753)
The panel 1	0.966	0.619	0.364	0.986	0.903 (0.819-0.957)
The panel 2	0.966	0.576	0.359	0.986	0.923 (0.843-0.970)
The panel 3	0.724	0.730	0.396	0.915	0.782 (0.678-0.864)
The panel 4	0.966	0.525	0.333	0.984	0.939 (0.865-0.980)