Research Article
An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism
Table 1
Analysis of genotype and allele distributions five SNPs TrkB gene for the whole population and stratified by sex.
| | SNP | Genotype
Allele | Control
n (%) | Patients
n (%) | | | Male | | | Female | | | Control
(%) | Patients
(%) | Control
(%) | Patients
(%) |
| | rs1867283 | G/G | 180 (27) | 98 (24) | 2.44 | 0.29 | 100 (29) | 56 (23) | 3.65 | 0.16 | 80 (26) | 42 (27) | 0.23 | 0.88 | | G/A | 309 (47) | 184 (46) | | | 153 (45) | 109 (45) | | | 156 (49) | 75 (47) | | | | A/A | 168 (26) | 119 (30) | | | 89 (26) | 77 (32) | | | 79 (25) | 42 (26) | | | | G | 669 (51) | 308 (47) | 2.34 | 0.12 | 353 (52) | 221 (46) | 3.77 | 0.06 | 316 (49) | 159 (50) | 0.01 | 0.99 | | A | 645 (49) | 422 (53) | | | 331 (48) | 263 (54) | | | 314 (51) | 159 (50) | | |
| | rs1565445 | A/A | 333 (51) | 208 (52) | 1.09 | 0.57 | 173 (50) | 128 (53) | 1.22 | 0.54 | 160 (51) | 80 (50) | 0.19 | 0.90 | | A/G | 259 (39) | 161 (40) | | | 133 (39) | 96 (39) | | | 126 (40) | 66 (42) | | | | G/G | 65 (10) | 32 (8) | | | 36 (11) | 19 (8) | | | 29 (9) | 13 (8) | | | | A | 925 (70) | 577 (72) | 0.50 | 0.47 | 479 (70) | 351 (73) | 0.73 | 039 | 446 (70) | 226 (71) | 0.01 | 0.99 | | G | 389 (30) | 225 (28) | | | 205 (30) | 133 (27) | | | 184 (30) | 92 (29) | | |
| | rs2769605 | C/C | 119 (18) | 86 (21) | 2.28 | 0.31 | 64 (19) | 49 (20) | 0.21 | 0.89 | 55 (18) | 37 (23) | 3.23 | 0.19 | | C/T | 326 (50) | 183 (46) | | | 161 (47) | 112 (46) | | | 165 (52) | 71 (45) | | | | T/T | 212 (32) | 132 (33) | | | 117 (34) | 81 (34) | | | 95 (30) | 51 (32) | | | | C | 564 (43) | 355 (44) | 0.31 | 0.57 | 289 (42) | 210 (43) | 0.11 | 0.74 | 275 (44) | 145 (46) | 0.25 | 0.61 | | T | 750 (57) | 447 (56) | | | 395 (58) | 274 (57) | | | 355 (56) | 173 (54) | | |
| | rs10868235 | C/C | 153 (23) | 105 (26) | 1.14 | 0.56 | 86 (25) | 57 (24) | 0.22 | 0.89 | 68 (22) | 48 (30) | 4.4 | 0.11 | | C/T | 334 (51) | 197 (49) | | | 173 (51) | 122 (50) | | | 161 (51) | 75 (47) | | | | T/T | 170 (26) | 99 (25) | | | 84 (24) | 63 (26) | | | 86 (27) | 36 (23) | | | | C | 640 (49) | 407 (51) | 0.75 | 0.38 | 343 (50) | 236 (49) | 0.16 | 0.68 | 297 (47) | 171 (54) | 3.5 | 0.06 | | T | 674 (51) | 395 (49) | | | 341 (49) | 248 (51) | | | 333 (52) | 147 (46) | | |
| | rs1387923 | A/A | 173 (27) | 76 (19) | 7.56 | <0.05 | 92 (27) | 45 (19) | 5.54 | 0.06 | 81 (26) | 31 (20) | 2.93 | 0.23 | | A/G | 310 (47) | 210 (52) | | | 159 (46) | 122 (50) | | | 151 (48) | 88 (55) | | | | G/G | 174 (26) | 115 (29) | | | 91 (27) | 75 (31) | | | 83 (26) | 40 (25) | | | | A | 656 (50) | 362 (45) | 4.38 | <0.05 | 343 (50) | 212 (44) | 4.32 | <0.05 | 313 (50) | 150 (47) | 0.43 | 0.51 | | G | 658 (50) | 440 (55) | | | 341 (50) | 272 (56) | | | 317 (50) | 168 (53) | | |
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