Disease Markers / 2020 / Article / Tab 3 / Research Article
Diagnostic Accuracy of Procalcitonin Compared to C-Reactive Protein and Interleukin 6 in Recognizing Gram-Negative Bloodstream Infection: A Meta-Analytic Study Table 3 Diagnostic performance of CRP and IL-6.
Author Year Optimal cutoff AUC (95% CI) Sensitivity Specificity GN episodes Total episodes CRP in 7371 episodes Bilgili [17 ] 2018 51.8 0.61 (0.512–0.716) 82.9 58.3 76 124 Brodska [18 ] 2013 86.2 0.705 (NR) 61.5 54.5 78 166 Fleischhack [21 ] 2000 50 NR (NR) 75.0 73.2 13 122 Fu [22 ] 2012 116 0.82 (NR) 82.6 75.0 23 43 Gao [23 ] 2017 74.65 0.953 (NR) 93.6 91.1 47 92 Koivula [24 ] 2011 100 NR (NR) 54.5 63.6 11 88 Li [27 ] 2016 59.25 0.678 (0.541–0.814) 74.7 65.7 158 298 Nakajima [30 ] 2014 475 0.738 (0.454-0.100 100.0 57.1 6 13 Prat [33 ] 2008 135 0.665 (0.475–0.856) 100.0 51.0 5 57 Shao [34 ] 2018 16 0.785 (NR) 62.7 87.0 170 379 Stoma [35 ] 2017 165 0.707 (0.564–0.825) 40.0 91.0 30 52 Xia [38 ] 2016 40 0.596 (0.527–0.666) 51.2 63.2 154 2819 Xu [39 ] 2019 90 0.557 (0.516–0.597) 44.7 80.0 217 3118 Pooled results with 95% CI (for CRP) 0.78 (0.74–0.81) 0.72 (0.59–0.81) 0.72 (0.63–0.79) Pooled results with 95% CI (for PCT) 0.85 (0.81–0.87) 0.73 (0.63–0.81) 0.81 (0.76–0.85) IL-6 in 3455 episodes Fleischhack [21 ] 2000 20 NR (NR) 44.4 80.2 13 122 Fu [22 ] 2012 186.5 0.82 (NR) 82.6 80 23 43 Gao [23 ] 2017 171.65 0.925 (NR) 93.6 90.5 47 92 Shao [34 ] 2018 75.7 0.74 (NR) 78.2 69.6 170 379 Xia [38 ] 2016 279.4 0.686 (0.622-0.750) 56.9 75.4 154 2819 Pooled results with 95% CI (for IL-6) 0.83 (0.80-0.86) 0.76 (0.58–0.88) 0.79 (0.71–0.85) Pooled results with 95% CI (for CRP) 0.85 (0.81–0.87) 0.75 (0.56–0.87) 0.80 (0.68–0.88) Pooled results with 95% CI (for PCT) 0.87 (0.84–0.90) 0.80 (0.60–0.91) 0.82 (0.72–0.89)
mg/L for CRP and pg/mL for IL-6; AUC: area under receiver operating characteristic curve; GN: Gram-negative; NR: not reported.