Serum Actinin-4 Levels as a Potential Diagnostic and Prognostic Marker in Cervical Cancer

Table 2

Univariate and multivariate Cox regression analysis of OS in CC patients.

Variables	Univariate			Multivariate
	HR	95% CI		HR	95% CI
Age (>45 vs. ≤45 years)	1.331	0.712–2.372	0.643	—
Pathological type (squamous cell carcinoma vs. adenocarcinoma)	1.106	0.903–1.341	0.874	—
FIGO stage (≥IB2 vs. IA1-IB1)	2.818	1.746–4.112	<0.001	2.015	1.464–3.046	0.017
Differentiation (poorly differentiated vs. well and moderately differentiated)	1.874	1.412–3.648	0.012	1.593	1.198–2.749	0.156
Lymph node involvement (positive vs. negative)	4.621	2.815–7.492	<0.001	2.907	1.315–7.124	<0.001
Tumor size (>2 vs. ≤2 cm)	1.536	1.115–2.896	0.257	—
Lymphovascular space invasion (positive vs. negative)	2.172	1.721–3.824	0.024	1.514	1.139–2.472	0.297
Serum ACTN4 levels (high vs. low levels)	2.442	1.806–4.113	<0.001	1.785	1.406–3.127	0.082