A Circulating Long Noncoding RNA Panel Serves as a Diagnostic Marker for Hepatocellular Carcinoma

Table 4

Correlation between serum level of lncRNAs PTENP1, PTTG3P, and SPRY4-IT1 and clinicopathological characteristics in 129 HCC patients.

Features	PTENP1			PTTG3P			SPRY4-IT1
	Low ()	High ()		Low ()	High ()		Low ()	High ()
Gender			0.972			0.136			0.636
Male	56	55		53	58		55	56
Female	9	9		12	6		10	8
Age			0.124			0.185			0.016
≤55	31	22		23	30		20	33
>55	34	42		42	34		45	31
HBsAg			0.558			0.870			0.496
Positive	49	51		50	50		52	48
Negative	16	13		15	14		13	16
AFP level			0.064			0.089			0.858
≤20 ng/mL	23	33		33	23		28	27
>20 ng/mL	42	31		32	41		36	37
Tumor size			0.897			0.612			0.530
≤3 cm	21	20		22	19		19	22
>3 cm	44	44		43	45		46	42
Tumor number			0.968			0.329			0.329
Single	54	53		56	51		56	51
Multiple	11	11		9	13		9	13
GGT (U/L)	90 (14-1034)	79.5 (13-2000)	0.611	70 (13-2000)	85.5 (14-1034)	0.042	86 (13-2000)	65 (15-710)	0.517
ALT (U/L)	38 (12-1198)	35 (7-402)	0.202	33 (7-402)	42.5 (12-1198)	0.316	33.5 (12-621)	49 (7-1198)	0.016
AST (U/L)	50 (17-1474)	38 (17-577)	0.306	37 (18-577)	52 (17-1474)	0.095	36.5 (17-412)	50 (18-1474)	0.097
TP (g/L)	68.2 (43.4-84.8)	69.1 (55.5-80.6)	0.504	68.6 (55.5-80.6)	68.6 (43.4-84.8)	0.983	68.6 (46.8-80.6)	68.7 (43.4-84.8)	0.243
ALB (g/L)	39.4 (21.4-48.6)	40.5 (23.8-48.9)	0.301	40.3 (23.8-48.9)	39.5 (21.4-48.6)	0.539	39.6 (21.4-48.9)	40.2 (23.6-48.6)	0.468

. AFP: alpha fetoprotein; GGT: gamma-glutamyl transpeptidase; ALT: alanine aminotransferase; AST: aspartic transaminase; TP: total protein; ALB: albumin.