Research Article
A Circulating Long Noncoding RNA Panel Serves as a Diagnostic Marker for Hepatocellular Carcinoma
Table 6
Performance of AFP, HULC, MALAT1, Linc00152, PTENP1, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 in HC and patients with HCC, CHB, and LC.
| | Method | HCC vs. HC | HCC vs. others# | | AUC (95% CI) | SEN (%) | SPE (%) | AUC (95% CI) | SEN (%) | SPE (%) |
| | AFP | 0.862 (0.815-0.909) | 65.9 | 97.8 | 0.811 (0.761-0.861) | 65.1 | 85.8 | | HULC | 0.796 (0.734-0.858) | 86.0 | 62.4 | 0.756 (0.702-0.810) | 86.0 | 55.6 | | MALAT1 | 0.768 (0.706-0.830) | 59.7 | 80.6 | 0.733 (0.676-0.790) | 59.7 | 75.7 | | Linc00152 | 0.895 (0.854-0.936) | 78.3 | 89.2 | 0.877 (0.835-0.918) | 81.4 | 82.8 | | PTENP1 | 0.602 (0.526-0.678) | 89.1 | 29.0 | 0.530 (0.465-0.596) | 89.1 | 23.1 | | PTTG3P | 0.785 (0.723-0.847) | 82.9 | 61.3 | 0.768 (0.715-0.820) | 82.9 | 57.4 | | SPRY4-IT1 | 0.808 (0.750-0.866) | 76.7 | 71.0 | 0.768 (0.715-0.821) | 76.7 | 67.5 | | UBE2CP3 | 0.812 (0.754-0.870) | 88.4 | 62.4 | 0.756 (0.702-0.810) | 78.3 | 60.4 | | UCA1 | 0.858 (0.810-0.907) | 81.4 | 75.3 | 0.809 (0.761-0.857) | 67.4 | 80.5 |
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#Others include HC, CHB patients, and LC patients. HCC: hepatocellular carcinoma; HC: healthy control; CHB: chronic hepatitis B; LC: liver cirrhosis; AFP: alpha fetoprotein; AUC: area under curve; CI: confidence interval; SEN: sensitivity; SPE: specificity.
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