Serum Golgi Protein 73 as a Potential Biomarker for Hepatic Necroinflammation in Population with Nonalcoholic Steatohepatitis

Table 3

Diagnostic values of GP73 for liver necroinflammation in NASH patients.

Stage	AUC	95% CI	Cutoff	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Youden index
GP73
	0.742	0.676-0.801	94.57	44.74	92.80	79.07	73.42	0.375	<0.0001
	0.891	0.840-0.931	101.1	88.89	85.94	22.87	99.40	0.748	<0.0001
ALT
	0.609	0.538-0.677	80.00	59.21	63.20	49.45	71.82	0.224	0.009
	0.576	0.505-0.646	110.00	66.67	56.77	6.75	97.32	0.234	0.457
AST
	0.667	0.597-0.731	54.00	47.37	76.80	55.38	70.60	0.242	<0.0001
	0.704	0.636-0.766	76.00	77.78	58.33	8.05	98.24	0.361	0.011

Abbreviation: AUC = area under the receiver operating characteristic curve; PPV = positive predictive value; NPV = negative predictive value; GP73 = Golgi protein 73; ALT = alanine transaminase; AST = aspartate aminotransferase.