Association of IL-1β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome

Table 3

Genotype and allele frequencies of IL-1β-511C/T, IL-6-174G/C, TNF-α-1031T/C, and TGFβ1-509T/C gene polymorphisms in RSA patients with or without PCOS and controls.

Gene polymorphism		RSA with PCOS	RSA without PCOS	Control	RSA with PCOS vs. control			RSA without PCOS vs. control			RSA with PCOS vs. RSA without PCOS
		(%)	(%)	(%)	OR (95% CI)			OR (95% CI)			OR (95% CI)
IL-1β-511C/T (rs16944)	CC	26 (37.7)	33 (47.9)	47 (33.8)	0.73 (0.35-1.47)	0.79	0.374	1.51 (3.43-0.66)	0.98	0.323	2.08 (0.85-5.09)	2.64	0.104
	CT	27 (39.1)	28 (39.4)	67 (48.2)	0.73 (0.37-1.40)	0.90	0.342	0.58 (0.31-1.07)	2.99	0.083	0.79 (0.38-1.65)	0.38	0.536
	TT	16 (23.2)	9 (12.7)	25 (18.0)	0.85 (0.46-1.54)	0.30	0.582	0.56 (0.31-0.99)	3.93	0.047	0.66 (0.33-1.29)	1.49	0.222
Allele	C	79 (57.3)	96 (67.6)	161 (57.9)	0.97 (0.64-1.47)	0.02	0.896	1.51 (0.99-2.31)	3.72	0.053	1.56 (0.95-2.53)	3.20	0.073
	T	59 (42.7)	46 (32.4)	117 (42.1)	1.03 (0.68-1.55)			0.66 (0.43-1.00)			0.64 (0.39-1.04)
IL-6-174G/C (rs1800795)	GG	42 (60.0)	43 (62.0)	88 (65.2)	0.28 (0.07-0.97)	4.50	0.033	0.69 (0.15-3.18)	0.23	0.634	2.52 (0.62-10.16)	1.78	0.181
	GC	21 (30.0)	24 (33.8)	43 (31.8)	0.28 (0.07-1.06)	3.81	0.050	0.74 (0.15-3.60)	0.14	0.712	2.67 (0.61-11.64)	1.78	0.181
	CC	7 (10.0)	3 (4.2)	4 (3.0)	1.25 (0.68-2.26)	0.53	0.464	1.15 (0.63-2.08)	0.21	0.647	0.92 (0.46-1.81)	0.06	0.810
Allele	G	105 (75.0)	112 (78.9)	219 (81.1)	0.70 (0.42-1.13)	2.08	0.149	0.87 (0.52-1.44)	0.30	0.587	0.87 (0.52-1.44)	0.60	0.440
	C	35 (25.0)	30 (21.1)	51 (18.9)	1.43 (0.87-2.33)			1.15 (0.69-1.90)			0.80 (0.46-1.40)
TNF-α-1031T/C (rs1799964)	TT	50 (73.5)	44 (62.5)	82 (59.9)	4.71 (0.58-37.97)	2.55	0.110	1.62 (0.42-6.17)	0.50	0.478	0.34 (0.03-3.38)	0.92	0.338
	TC	17 (25.0)	23 (33.3)	46 (33.6)	3.33 (0.39-28.25)	1.34	0.247	1.57 (0.38-6.32)	0.40	0.527	0.47 (0.04-4.91)	0.41	0.521
	CC	1 (1.5)	3 (4.2)	9 (6.5)	0.54 (0.28-1.01)	3.71	0.054	0.90 (0.49-1.60)	0.14	0.709	1.67 (0.81-3.42)	1.95	0.162
Allele	T	117 (86.0)	114 (79.2)	210 (76.6)	1.88 (1.07-3.28)	4.96	0.025	1.16 (0.71-1.89)	0.35	0.556	0.62 (0.32-1.15)	2.28	0.130
	C	19 (14.0)	30 (20.8)	64 (23.4)	0.53 (0.30-0.93)			0.86 (0.52-1.40)			1.62 (0.86-3.04)
TGFβ1-509T/C (rs1800469)	TT	29 (42.0)	30 (42.9)	60 (44.5)	1.17 (0.48-2.85)	0.12	0.724	2.54 (0.82-7.81)	2.79	0.094	2.16 (0.62-7.55)	1.52	0.217
	TC	32 (46.4)	36 (51.4)	57 (42.2)	1.26 (0.49-3.22)	0.24	0.625	2.84 (0.89-9.07)	3.30	0.069	2.25 (0.61-8.18)	1.57	0.210
	CC	8 (11.6)	4 (5.7)	18 (13.3)	1.10 (0.61-1.98)	0.11	0.742	1.07 (0.59-1.91)	0.05	0.828	0.97 (0.49-1.89)	0.01	0.921
Allele	T	90 (65.2)	96 (68.6)	177 (65.6)	0.99 (0.64-1.51)	0.00	0.945	1.15 (0.74-1.77)	0.38	0.539	1.16 (0.70-1.91)	0.35	0.552
	C	48 (34.8)	44 (31.4)	93 (34.4)	1.02 (0.66-1.56)			0.87 (0.56-1.34)			0.86 (0.52-1.41)

OR: odds ratio; CI: confidence interval; significant difference.