Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3K/Akt/mTOR Signaling Pathway in HER2+ Breast Cancer

Table 3

Cox’s multivariate regression analysis of the patient survival in breast cancer with respect to clinical parameters and cancer biological factors.

Variables	^a	DFS; HR (95% CI)^b		OS; HR (95% CI)^b
Lymph node status			0.001		0.112
Negative	120	1		1
Positive	96	1.863 (1.291-2.687)		1.712 (0.882-3.323)
HER2 status			<0.001		<0.001
Negative	91	1		1
Positive	125	2.133 (1.432-3.178)		4.959 (2.046-12.020)
SGLT1			0.001		0.002
Low	100	1		1
High	116	1.891 (1.297-2.756)		2.935 (1.469-5.865)

Significant values () are indicated in bold. ^aNumber of patients. ^bHazard ratio (HR) (CI confidence interval) of Cox’s multivariate regression analysis.