Research Article
Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation
Table 1
Basal characteristics of the two study cohorts and the control group. Values in median and range.
| | Tx cohort | CKD cohort | Healthy controls |
| | 53 | 83 | 40 | | Age (years) | 12.2 (2.3–18.0) | 10.1 (2.0–17.5) | 6.7 (4.8–8) | | Male (, %) | 32 (60%) | 49 (59%) | | | Weight (kg) | 39.3 (11.1–90.4) | 30.8 (8.96–84.6) | | | Weight -score | -0.45 (-2.60–3.10) | -0.31 (-3.43–2.66) | | | Height (cm) | 142 (83–184) | 137 (74–177) | | | Height -score | -1.52 (-4.4–0.5) | -0.53 (-4.63–2.04) | | | BMI (kg/m2) | 17.9 (14.2–35.4) | 17.0 (12.7–33.2) | | | BMI -score | 0.34 (-1.49–2.97) | 0.20 (-3.30–2.75) | | | Overweight/obesity (, %) | 12/5 (23/9) | 11/3 (13/4) | | | Age at Rtx1 (years) | 4.4 (0.8–15.8) | — | | | Time from Rtx1 (years) | 5.0 (1.0–15.5) | — | | | Preemptive Rtx1 (, %) | 25 (47%) | — | | | Total dialysis (months) | 9.5 (0.25–39.5) | — | | | Rtx1/Rtx2 | 51/2 | — | | | LD/DD (, %) | 48/5 (91%) | — | | | mGFR (mL/min/1.73 m2)a | 56 (24–111) | 73 (14–143) | | | Hemoglobin (g/dL) | 12.2 (7.1–14.8) | 12.5 (8.7–15.5) | | | HbA1c (%) | 5.2 (4.2–7.8) | — | | | Protein/creatinine ratio (mg/mmol) | 16 (6–193) | 27 (3–1084) | | | <15 mg/mmol (, %) | 24 (46%) | 26 (31%) | | | 15–50 mg/mmol (, %) | 22 (42%) | 29 (35%) | | | >50 mg/mmol (, %) | 6 (11%) | 28 (34%) | | | Etiology of ESRD/CKD | | | | | CAKUT | 23 (43%) | 27 (33%) | | | Hereditary | 13 (25%) | 23 (28%) | | | Glomerulonephritis | 8 (15%) | 9 (11%) | | | Acquired | 7 (13%) | 10 (12%) | | | Vesiculoureter reflux | — | 7 (8%) | | | Miscellaneous/unknown | 2 (4%) | 7 (8%) | |
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aFor two patients in the Tx cohort, the mGFR is missing because of low GFR, replaced with eGFR.
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