SEPT9 Gene Methylation as a Noninvasive Marker for Hepatocellular Carcinoma

Figure 2

The receiver operating characteristic (ROC) curve of plasma SEPT9 methylation (mSEPT9) and serum alpha fetoprotein (AFP) in the diagnosis of HCC and early-stage HCC from the healthy control group and the at-risk disease group. The ROC curves of plasma mSEPT9 with and without the inclusion of AFP and AFP alone for HCC patients versus HC (a), early-stage HCC patients versus HC (b), HCC patients versus at-risk disease (c), and early-stage HCC patients versus at-risk disease (d). HCC indicates hepatocellular carcinoma. HC indicates healthy control. At-risk indicates noncancerous liver diseases including cirrhosis and hepatitis.

(a)

(b)

(c)

(d)