| Variable | Crude model | Model I | Model II | HR (95% CIs) | value | HR (95% CIs) | value | HR (95%CIs) | value |
| 30-day all-cause mortality | | | | | | | Anion gap (mmol/L) | 1.11 (1.10, 1.12) | <0.0001 | 1.11 (1.10, 1.12) | <0.0001 | 1.07 (1.06, 1.09) | <0.0001 | Anion gap (tertile) (mmol/L) | | | | | | | <12 | 1.0 (ref) | | 1.0 (ref) | | 1.0 (ref) | | ≥12, <14 | 1.13 (1.00, 1.27) | 0.0568 | 1.08 (0.96, 1.22) | 0.2017 | 1.08 (0.91, 1.26) | 0.3774 | ≥14 | 1.89 (1.71, 2.09) | <0.0001 | 1.81 (1.63, 2.00) | <0.0001 | 1.54 (1.33, 1.75) | <0.0001 | for trend | <0.0001 | | <0.0001 | | <0.0001 | | 90-day all-cause mortality | | | | | | | Anion gap (mmol/L) | 1.10 (1.09, 1.11) | <0.0001 | 1.10 (1.09, 1.11) | <0.0001 | 1.08 (1.06, 1.10) | <0.0001 | Anion gap (tertile) (mmol/L) | | | | | | | <12 | 1.0 (ref) | | 1.0 (ref) | | 1.0 (ref) | | ≥12, <14 | 1.13 (1.02, 1.25) | 0.0216 | 1.08 (0.98, 1.20) | 0.1340 | 1.09 (0.95, 1.25) | 0.1452 | ≥14 | 1.78 (1.64, 1.94) | <0.0001 | 1.70 (1.56, 1.85) | <0.0001 | 1.55 (1.38, 1.73) | <0.0001 | for trend | <0.0001 | | <0.0001 | | <0.0001 | | 365-day all-cause mortality | | | | | | | Anion gap (mmol/L) | 1.08 (1.08, 1.09) | <0.0001 | 1.09 (1.08, 1.09) | <0.0001 | 1.08 (1.06, 1.09) | 0.0002 | Anion gap (tertile) (mmol/L) | | | | | | | <12 | 1.0 (ref) | | 1.0 (ref) | | 1.0 (ref) | | ≥12, <14 | 1.14 (1.05, 1.25) | 0.0019 | 1.10 (1.01, 1.19) | 0.0344 | 1.14 (1.03, 1.24) | 0.0122 | ≥14 | 1.64 (1.52, 1.76) | <0.0001 | 1.56 (1.45, 1.68) | <0.0001 | 1.46 (1.31, 1.60) | <0.0001 | for trend | <0.0001 | | <0.0001 | | <0.0001 | |
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HR: hazard ratio; CI: confidence interval. Models were derived from Cox proportional hazards regression models. Crude model adjusted for: none. Model I adjusted for: age and gender. Model II adjusted for: age, gender, acute kidney injury stage, congestive heart failure, coronary artery disease, liver disease, stroke, respiratory failure, pneumonia, SIRS, potassium, albumin, platelet, BUN, PT, INR, APTT, WBC, creatinine, lactate, pH, bicarbonate, sodium, chloride, diabetes, bilirubin, renal replacement therapy, respiration rate, SPO2, heart rate, systolic blood pressure, diastolic blood pressure, temperature, Elixhauser comorbidity index, SOFA, and SAPSII.
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