Clinical and Prognostic Implications of P21 (WAF1/CIP1) Expression in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis

Table 2

The main characteristics of studies investigating the prognostic value of P21 and overall survival.

Study	HR	LL	UL	Survival	Statistical method
Sarbia M 1998	0.556	0.347	0.885	OS	Multivariable
Kuwahara M 1999	3.409	1.388	8.373	OS	Multivariable
Natsugoe S 1999	1.920	1.065	3.460	OS	Survival curve
Shimada Y 1999	2.398	1.477	3.906	OS	Multivariable
Lam KY 1999	0.627	0.411	0.956	OS	Survival curve
Nita ME 1999	1.713	1.022	2.871	OS	Multivariable
GUNER D 2003	0.435	0.200	0.943	OS	Multivariable
Nakamura T 2004	1.530	1.040	2.330	OS	Multivariable
Goan YG 2005	0.549	0.308	0.980	OS	Multivariable
Lin CD 2010	2.322	1.091	4.940	OS	Univariate
Taghavi N 2010	3.946	0.430	30.860	OS	Multivariable
Liu J 2012	2.139	1.199	3.816	OS	Survival curve
Shiozaki A 2013	2.379	1.700	3.313	OS	Multivariable
Zhang Y 2014	1.867	1.029	3.387	OS	Multivariable
Lin Y 2016	2.623	1.005	8.147	OS	Multivariable

Note: HR = hazard ratio; LL = lower confidence interval limit; UL = upper confidence interval limit; OS = overall survival.