Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells

Table 6

The topological characteristics of overlapped DEGs in the PPI network of NSPC-induced EC genetic alterations. The overlapped DEGs mean these DEGs were overlapped between the PPI network of NSPC-induced EC alteration and the PPI network of EC-induced NSPC alteration.

Overlapped DEGs	Regulate	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Topological coefficient
Timp3	Down	21	3.394397	0.012355	0.294603	0.193591
Mmp14	Down	15	3.321121	0.006668	0.301103	0.213333
Col11a1	Down	14	3.681034	0.000966	0.271663	0.265873
H3f3b	Up	13	3.793103		0.263636	0.329522
Loxl1	Down	13	3.568966	0.001462	0.280193	0.254605
Ccp110	Up	12	3.497845	0.007609	0.28589	0.324906
Rpl30	Up	12	3.715517	0.001937	0.269142	0.208333
Irs1	Down	11	3.103448	0.01987	0.322222	0.171937
Aldh1a1	Down	9	3.403017	0.022894	0.293857	0.139918
P4ha2	Down	9	3.913793	0.00226	0.255507	0.381313
Cck	Up	8	3.579741	0.011327	0.27935	0.194444
Plod2	Down	8	4.118534		0.242805	0.428977
Rhoq	Down	8	4.008621	0.012817	0.249462	0.156863
H6pd	Down	7	3.534483	0.017785	0.282927	0.159664
Luc7l3	Up	7	3.571121	0.009536	0.280024	0.188065
Dlx5	Up	6	3.784483	0.007836	0.264237	0.215278
Rcn3	Down	6	3.525862	0.008417	0.283619	0.330247
F3	Down	5	3.56681		0.280363	0.413514
Hspa2	Down	5	3.221983	0.000827	0.310368	0.275229
Tgm2	Down	5	3.538793	0.005005	0.282582	0.379221
Aldh1a7	Down	4	4.165948	0.000317	0.240041	0.416667
Irgm2	Down	4	4.290948	0.000557	0.233049	0.3125
Smad6	Down	4	3.928879	0.002692	0.254526	0.289474
Bmper	Down	3	4.810345	0.000753	0.207885	0.433333
Daam2	Down	3	3.87931	0.008654	0.257778	0.333333
Rras	Down	3	4.3125	0.000343	0.231884	0.439394
Syde1	Down	3	4.939655	0.000344	0.202443	0.545455
Tns1	Down	3	4.286638	0.002258	0.233283	0.355556
Fcgrt	Down	2	4.157328	0	0.240539	0.576923
Rin2	Down	2	4.681034	0.000218	0.213628	0.5
Sdpr	Down	2	4.275862	0.000187	0.233871	0.5
Slc2a10	Down	2	4.176724	0	0.239422	0.738095