Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells

Table 7

The topological characteristics of overlapped DEGs in the PPI network of EC-induced NSPC genetic alterations. The overlapped DEGs mean these DEGs were overlapped between the PPI network of NSPC-induced EC alteration and the PPI network of EC-induced NSPC alteration.

Overlapped DEGs	Regulate	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Topological coefficient
H6pd	Down	39	2.905639	0.018002	0.344158	0.081197
Mmp2	Down	30	2.905639	0.009375	0.344158	0.111791
Cck	Up	24	3.161105	0.002392	0.316345	0.14388
Irs1	Down	24	2.90794	0.011375	0.343886	0.090661
Igfbp5	Down	18	3.002302	0.001391	0.333078	0.145524
Loxl1	Down	18	3.331415	0.002588	0.300173	0.154147
Mmp14	Down	18	2.958573	0.006212	0.338001	0.147655
Aldh1a1	Down	16	3.079402	0.008487	0.324738	0.124419
Plod2	Down	16	3.535098	0.002197	0.282878	0.168269
Col11a1	Down	15	3.464902	0.007219	0.288608	0.154386
Timp3	Down	15	3.065593	0.004764	0.326201	0.152648
Irgm2	Down	14	3.910242		0.255739	0.348397
P4ha2	Down	14	3.637514	0.001633	0.274913	0.177721
Rhoq	Down	13	3.673188	0.001094	0.272243	0.173382
F3	Down	11	3.150748	0.00066	0.317385	0.188776
Dlx5	Up	10	3.500575	0.001701	0.285667	0.221359
Hspa2	Down	10	3.356732	0.009675	0.297909	0.113084
Luc7l3	Up	9	3.771001	0.004972	0.265182	0.17284
Syde1	Down	9	3.562716	0.005367	0.280685	0.202822
Tgm2	Down	9	3.103567	0.002864	0.32221	0.194714
Rras	Down	8	3.651323	0.00461	0.273873	0.227113
Sdpr	Down	8	3.372842	0.002511	0.296486	0.180118
Aldh1a7	Down	7	3.686997	0.000587	0.271223	0.221254
Ccp110	Up	7	3.982739	0.002565	0.251084	0.159664
Cdc7	Up	7	3.821634	0.000152	0.261668	0.313589
Rcn3	Down	7	3.697353	0.000432	0.270464	0.249433
Tns1	Down	7	3.397008	0.005802	0.294377	0.188729
Zcchc12	Up	6	3.775604	0.006142	0.264858	0.217391
Akap12	Down	5	3.422325	0.002599	0.292199	0.261111
Daam2	Down	5	3.658228	0.000694	0.273356	0.303226
H3f3b	Up	5	4.362486		0.229227	0.5125
Rpl30	Up	5	4.084005	0.000687	0.244858	0.3
Sema3c	Down	5	3.528193	0.002593	0.283431	0.2075
Smad6	Down	5	3.510932	0.001004	0.284825	0.284848
Bmper	Down	4	4.210587	0.00075	0.237497	0.26
Rin2	Down	4	3.874568	0.002452	0.258093	0.25
Gem	Down	3	3.882624	0.002302	0.257558	0.42735
Selenbp1	Down	3	4.462601	0.000293	0.224085	0.458333
Fcgrt	Down	2	3.943613		0.253575	0.5
Slc2a10	Down	2	3.864212		0.258785	0.5
Sytl2	Down	2	3.759494	0.000207	0.265993	0.5
Fam102a	Down	1	5.730725	0	0.174498	0
Macrod1	Down	1	5.880322	0	0.170059	0
Pdgfrl	Down	1	4.286536	0	0.233289	0