Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells

Table 8

The topological characteristics of the top 30 nodes in the TF-target DEG interaction network involved in the NSPC-induced EC alteration.

Name	Label	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Topological coefficient
Ptgs2	Upregulated DEG	30	3.17073171	0.25370241	0.31538462	0.07348485
Il6	Upregulated DEG	20	3.31300813	0.16071429	0.30184049	0.10921053
Serpine1	Upregulated DEG	19	3.40650407	0.10638454	0.29355609	0.09078947
Mmp9	Downregulated DEG	18	3.25203252	0.16761464	0.3075	0.11243386
Sp1	TF	15	3.17479675	0.15105709	0.31498079	0.10813008
Nfkb1	TF	14	2.99593496	0.17606132	0.33378562	0.11316212
Mmp2	Downregulated DEG	13	3.45121951	0.05861543	0.28975265	0.16008316
Fgf10	Downregulated DEG	13	4.18699187	0.10945704	0.23883495	0.07692308
Trp53	TF	13	3.42276423	0.10326907	0.29216152	0.10697115
Jun	TF	13	3.14634146	0.14436348	0.31782946	0.12725546
Twist1	Downregulated DEG_TF	12	3.50406504	0.13470851	0.28538283	0.13288288
Col1a1	Downregulated DEG	12	3.4796748	0.11936909	0.28738318	0.13709677
Birc5	Upregulated DEG	11	3.53252033	0.1098108	0.283084	0.13636364
Csf2	Upregulated DEG	10	3.51626016	0.08268292	0.28439306	0.16071429
Smad6	Downregulated DEG	9	4.94715447	0.04322026	0.2021364	0.12698413
Stat3	TF	9	3.43495935	0.09055949	0.29112426	0.15065913
Egr1	TF	9	3.76829268	0.05361397	0.26537217	0.13947991
Nfe2l2	Upregulated DEG_TF	8	3.89430894	0.03472983	0.25678497	0.15972222
Rela	TF	8	3.33333333	0.05841757	0.3	0.18382353
Ep300	TF	8	3.52439024	0.04168611	0.28373702	0.19067797
Upp1	Upregulated DEG	7	3.58536585	0.04680464	0.27891156	0.1978022
Igf2	Downregulated DEG	7	5.18292683	0.04071495	0.19294118	0.14285714
Ebf1	Downregulated DEG_TF	7	4.57723577	0.04361263	0.21847247	0.14285714
Fos	TF	6	3.82926829	0.01974273	0.2611465	0.22727273
Dcstamp	Upregulated DEG	6	3.75203252	0.02000123	0.26652221	0.25396825
Nqo1	Upregulated DEG	5	3.83333333	0.02317522	0.26086957	0.21904762
Ndrg1	Downregulated DEG	5	3.83333333	0.02104419	0.26086957	0.27142857
Mmp14	Downregulated DEG	5	3.81707317	0.01378142	0.26198083	0.29
Maf	Downregulated DEG_TF	5	3.84146341	0.0340471	0.26031746	0.28571429
Hspa1b	Downregulated DEG	5	3.88211382	0.05662735	0.25759162	0.24545455