Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells

Table 9

The topological characteristics of the top 30 nodes in the TF-target DEG interaction network involved in the EC-induced NSPC alteration.

Name	Label	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Topological coefficient
Cdkn1a	Downregulated DEG	65	2.73913043	0.30858346	0.36507937	0.0283698
Ccnd1	Downregulated DEG_TF	44	2.90096618	0.18721585	0.34471274	0.0390556
Sp1	TF	38	2.75120773	0.18665254	0.36347673	0.04086687
Fos	Downregulated DEG_TF	37	2.89855072	0.15489676	0.345	0.05012705
Vegfa	Downregulated DEG	24	3.09178744	0.1032236	0.3234375	0.06904762
Hes1	Downregulated DEG_TF	21	3.26328502	0.093159	0.30643967	0.06776557
Cdkn2a	Downregulated DEG	20	3.16183575	0.06806015	0.31627196	0.0622093
Nfkb1	TF	19	2.83091787	0.10896078	0.35324232	0.078356
Cebpb	Downregulated DEG_TF	15	3.01690821	0.0630859	0.33146517	0.07979003
Acta2	Downregulated DEG	14	3.41062802	0.04841393	0.29320113	0.10449735
Trp53	TF	14	3.23188406	0.04815141	0.30941704	0.09895151
Jun	TF	14	3.25603865	0.03607564	0.30712166	0.10204082
Mmp2	Downregulated DEG	13	3.08937198	0.03126342	0.32369038	0.11609687
Ep300	TF	12	3.13043478	0.05353532	0.31944444	0.11131841
Cdkn2b	Downregulated DEG	12	3.80917874	0.03041314	0.26252378	0.10714286
Nfe2l2	Downregulated DEG_TF	12	3.26570048	0.04141463	0.30621302	0.10585586
Rela	TF	11	3.21497585	0.03799736	0.31104433	0.118411
Nr3c1	Downregulated DEG_TF	11	3.24637681	0.03066868	0.30803571	0.11162255
Smad6	Downregulated DEG_TF	11	3.73671498	0.02413405	0.26761474	0.11004785
Sp3	TF	10	3.35990338	0.01668852	0.29762761	0.12268041
Stat3	TF	10	3.33816425	0.03841092	0.29956585	0.13235294
Id3	Downregulated DEG	10	3.82125604	0.02673839	0.26169406	0.10869565
Smad3	TF	9	3.72463768	0.03330304	0.26848249	0.14403292
Egr1	TF	9	3.57004831	0.03896833	0.28010825	0.12007168
Mbp	Downregulated DEG	9	3.52415459	0.02687184	0.283756	0.13888889
Srebf1	TF	8	3.59903382	0.0307691	0.27785235	0.13380282
Myc	TF	8	3.36231884	0.02336862	0.29741379	0.14650538
Id1	Downregulated DEG_TF	8	3.2826087	0.02185908	0.30463576	0.13903061
Cebpd	Downregulated DEG	8	3.43236715	0.01679448	0.29134412	0.16163793
Pdk4	Downregulated DEG	8	3.61111111	0.01282401	0.27692308	0.19396552