Expression and Significance of Insulin Receptor Substrate 1 in Human Hepatocellular Carcinoma

Table 4

Univariate and multivariate analyses for the association of baseline characteristics with IRS-1 expression in total 140 patients.

Variables	IRS-1 expression		Univariate	Multivariate analysis^†
	Positive	Negative	value	Adjusted OR	95% CI	value
Age (years), (%)
≥55	25 (35.2)	46 (64.8)	0.547	1.121	0.509-2.470	0.776
<55	21 (30.4)	48 (69.6)	—
Sex, (%)
Male	34 (37.0)	58 (63.0)	0.153	1.818	0.778-4.247	0.167
Female	12 (25.0)	36 (75.0)	—
HBV, (%)
Positive	26 (29.5)	62 (70.5)	0.278	0.390	0.169-0.904	0.028
Negative	20 (38.5)	32 (61.5)	—
HCV, (%)
Positive	2 (18.2)	9 (81.8)	0.456	0.215	0.040-1.160	0.074
Negative	44 (34.1)	85 (65.9)	—
HCC patients, (%)
HCC	41 (41.0)	59 (59.0)	0.001	6.60	2.243-19.425	0.001
Non-HCC	5 (12.5)	35 (87.5)	—

CI: confidence interval; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; HCV; hepatitis C virus; OR: odds ratio, , , ^†In our multivariate analysis, 5 variables were entered, including age which was regrouped into two groups with the cutoff of 55 years old, sex, infection status of HBV, infection status of HCV, and pathologic diagnosis of HCC or others.