Septin 9 Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma

Figure 1

Frequent methylation and downregulation of Septin 9 in NPC. (a) Amplification curves of Septin 9 in nasopharyngeal tissues of patients with NPC and nasopharyngitis by qMS-PCR. (b) Comparison of Septin 9 methylation levels in NPC and nasopharyngitis biopsies. (c) Relative expression of Septin 9 in NPC and chronic nasopharyngitis. The expression level of Septin 9 mRNA was determined using qRT-PCR and normalized to the housekeeping gene (GAPDH).

(a)

(b)

(c)