Upregulated Seizure-Related 6 Homolog-Like 2 Is a Prognostic Predictor of Hepatocellular Carcinoma

Table 2

Cox proportional-hazard regression analysis for overall survival.

Variables	Univariable analysis			Multivariable analysis
	HR		95% CI	HR		95% CI
Gender	1.252	0.452	0.697-2.250
Age	1.313	0.359	0.734-2.349
TNM stage	1.960	0.025	1.088-3.533	1.511	0.209	0.794-2.874
Cancer embolus	1.550	0.171	0.828-2.901
HBV+HCV+	1.316	0.370	0.722-2.396
Tumor number	0.547	0.082	0.277-1.081	0.590	0.171	0.277-1.256
Tumor size (≥2 cm)	0.534	0.044	0.290-0.983	0.461	0.024	0.235-0.905
AFP	2.610	0.003	1.389-4.903	2.262	0.014	1.176-4.349
Pathological grading	1.005	0.983	0.541-1.869
SEZ6L2	1.928	0.031	1.061-3.502	2.499	0.008	1.276-4.893

Abbreviations: CI: confidence interval; HR: hazard ratio; AFP: alpha-fetoprotein; HBV: hepatitis B virus; HCV: hepatitis C virus.